Treating Chronic Fatigue Syndrome (ME/CFS): Coenzyme Q10
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Coenzyme Q10 (Co Q10) is an important factor in our
cell's energy production and is(in its reduced form (CoQ)) an antioxidant as
well. Clinical trials involving Co Q10 have taken place in over 20 disorders
including high blood pressure, Alzheimer’s, cardiomyopathy, heart failure, AIDS
and mitochondrial diseases. According to the Mayo Clinic COQ10 has had positive
affects in many small trials but more research is needed before recommendations
can be made regarding its use.
Co Q10 May Work in Chronic Fatigue Syndrome (ME/CFS) Because
of its antioxidant properties and its ability to enhance cellular energy
production. Chronic fatigue syndrome (ME/CFS) studies consistently show
increased rates of oxidative stress. Some researchers believe cellular
energy production is impaired in chronic fatigue syndrome (ME/CFS)
Chronic Fatigue Syndrome (ME/CFS) and FM Studies: No
studies have examined Co Q10 efficacy in CFS or FM. There are many anecdotal
reports of its beneficial effects and CFS practitioners often prescribe it. Dr. Klimas reported
it was the best antioxidant available. Dr. Lapp reported COQ10 give about 10-15%
improvement in about half his patients.
Dose: Reported doses have ranged from 30-300 mg/day
often taken in divided doses. Dr. Klimas and Dr. Lapp recommend trying 120 mg/day. Co q10 is fat-soluble, so it is better absorbed
when taken with a meal that contains oil or fat. It may take up to eight weeks
to see effects.
Side Effects: Few reported but may include nausea,
itching loss of appetite, fatigue, flu-like symptoms at higher doses. Since Co
Q10 may reduce blood sugar levels caution is advised in diabetes or hypoglycemia
patients. CoQ10 may reduce blood pressure or lower blood cholesterol levels. If
side effects occur try breaking up the dose.
Increasing Energy
Production in Chronic Fatigue Syndrome (ME/CFS)
(This and all sections of
the Phoenix Rising website are compiled by a layman. They are not a substitute
for a physician and are for informational uses only. Please discuss any
treatments in these pages with your physician.)
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Mayo clinic: CoQ10
Oregon State, Linus Pauling Institute: Micronutrient Center.