A Guide to the Brain In Chronic Fatigue Syndrome (ME/CFS)  by Cort Johnson

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The central nervous system has become an ever increasing focus of research. Four papers examine differing aspects of this fascinating subject.

The Fatigue in Chronic Fatigue Syndrome (ME/CFS) - Is it 'Central'?  - Examine the increasing evidence that the brain plays a pivotal role in the fatigue found in CFS. This paper examines the type of fatigue found in  the CFS, which parts of the brain it may come from and what may cause.

Choline on the Brain? Several studies have indicated that increased choline production occurs in one part of the brain in CFS.

 A Neurological Channelopathy in Chronic Fatigue Syndrome (ME/CFS)? The question whether a 'channelopathy' - a dysfunction in the ion channels that regulate the flows of substances into cells - has gained increased prominence over time. This difficult paper asks if the central nervous system abnormalities in CFS due to an ion channel dysfunction

.A 'Selfish Brain' in Chronic Fatigue Syndrome (ME/CFS)?  - Following on the work of the CDC's Pharmacogenomic's project, this paper asks if an altered energy 'set point' in the brains of CFS patients could be at the heart of CFS?